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caspase 1 inhibitor vx 765  (MedChemExpress)


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    Structured Review

    MedChemExpress caspase 1 inhibitor vx 765
    Caspase 1 Inhibitor Vx 765, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 97/100, based on 228 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/caspase+1+inhibitor+vx/Belnacasan/pm42302943-118-13-20
    Average 97 stars, based on 228 article reviews
    caspase 1 inhibitor vx 765 - by Bioz Stars, 2026-09
    97/100 stars

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    Related Articles

    Expressing:

    Article Title: ABT-737 efficiently inhibits hepatocellular carcinoma cell activity via regulating PANoptosis
    Article Snippet: The necroptosis inhibitor Necrostatin-1 (Nec-1) and the caspase-1 inhibitor VX-765 were purchased from MedChemExpress (USA).

    Cell Culture:

    Article Title: ABT-737 efficiently inhibits hepatocellular carcinoma cell activity via regulating PANoptosis
    Article Snippet: The necroptosis inhibitor Necrostatin-1 (Nec-1) and the caspase-1 inhibitor VX-765 were purchased from MedChemExpress (USA).

    Western Blot:

    Article Title: ABT-737 efficiently inhibits hepatocellular carcinoma cell activity via regulating PANoptosis
    Article Snippet: The necroptosis inhibitor Necrostatin-1 (Nec-1) and the caspase-1 inhibitor VX-765 were purchased from MedChemExpress (USA).

    Control:

    Article Title: ABT-737 efficiently inhibits hepatocellular carcinoma cell activity via regulating PANoptosis
    Article Snippet: The necroptosis inhibitor Necrostatin-1 (Nec-1) and the caspase-1 inhibitor VX-765 were purchased from MedChemExpress (USA).



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    Effect of ABT-737 on PANoptosis-related protein expression in cultured cells. A, B Western blot analysis and quantification of necroptosis markers (RIPK1, RIPK3, MLKL, pMLKL). C, D Apoptosis markers (caspase-3, cleaved caspase-3, Bax, Bcl-2). E, F Pyroptosis markers (NLRP3, ASC, <t>caspase-1).</t> β-actin was used as loading control. Data are presented as mean ± SD ( n = 3). * P < 0.05, ** P < 0.01, *** P < 0.001 vs. control
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    Effect of ABT-737 on PANoptosis-related protein expression in cultured cells. A, B Western blot analysis and quantification of necroptosis markers (RIPK1, RIPK3, MLKL, pMLKL). C, D Apoptosis markers (caspase-3, cleaved caspase-3, Bax, Bcl-2). E, F Pyroptosis markers (NLRP3, ASC, <t>caspase-1).</t> β-actin was used as loading control. Data are presented as mean ± SD ( n = 3). * P < 0.05, ** P < 0.01, *** P < 0.001 vs. control
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    Image Search Results


    Effect of ABT-737 on PANoptosis-related protein expression in cultured cells. A, B Western blot analysis and quantification of necroptosis markers (RIPK1, RIPK3, MLKL, pMLKL). C, D Apoptosis markers (caspase-3, cleaved caspase-3, Bax, Bcl-2). E, F Pyroptosis markers (NLRP3, ASC, caspase-1). β-actin was used as loading control. Data are presented as mean ± SD ( n = 3). * P < 0.05, ** P < 0.01, *** P < 0.001 vs. control

    Journal: Discover Oncology

    Article Title: ABT-737 efficiently inhibits hepatocellular carcinoma cell activity via regulating PANoptosis

    doi: 10.1007/s12672-026-04684-z

    Figure Lengend Snippet: Effect of ABT-737 on PANoptosis-related protein expression in cultured cells. A, B Western blot analysis and quantification of necroptosis markers (RIPK1, RIPK3, MLKL, pMLKL). C, D Apoptosis markers (caspase-3, cleaved caspase-3, Bax, Bcl-2). E, F Pyroptosis markers (NLRP3, ASC, caspase-1). β-actin was used as loading control. Data are presented as mean ± SD ( n = 3). * P < 0.05, ** P < 0.01, *** P < 0.001 vs. control

    Article Snippet: The necroptosis inhibitor Necrostatin-1 (Nec-1) and the caspase-1 inhibitor VX-765 were purchased from MedChemExpress (USA).

    Techniques: Expressing, Cell Culture, Western Blot, Control

    (A) Overview of NLRP3 inflammasome priming and activation. DAMPs = damage-associated molecular patterns. TLR = Toll-like receptor. PAMPs = pathogen-associated molecular pattern. (B) IL-1β and IL-18 release by hMDMs ( n = 14 donors). (C) IL-1β release by mBMDMs ( n = 10). (D) IL-1β release by hMDMs in the presence of the inflammasome inhibitors KCl ( n = 8 donors) or VX-765 ( n = 9 donors). (E) Percentage ASC-positive mBMDMs ( n = 3 uninfected , n = 4 infected). (F, G) IL-1β release of mBMDMs deficient in the NLRP3 receptor ( Nlrp3 −/− ), the adapter proteins ASC ( Pycard −/− ) or the proteolytic enzyme caspase 1 ( Casp1 −/− / Casp11 −/− ) ( n = 4) or deficient in gasdermin D ( Gsdmd −/− ) (G). Bars represent the mean + SEM with dots as individual biological replicates: Individual donors (B, D) or mice (C, E - G) from at least three independently conducted experiments. Statistical significance was determined using a two-way ANOVA including with Holm-Šídák post-hoc test. * = P ≤ 0.05, ** = P ≤ 0.01, *** = P ≤ 0.001, **** = P ≤ 0.0001

    Journal: bioRxiv

    Article Title: Local albumin excess exacerbates Candida albicans-induced inflammasome activation linked with hyperinflammation during vulvovaginal candidiasis

    doi: 10.64898/2026.01.22.700771

    Figure Lengend Snippet: (A) Overview of NLRP3 inflammasome priming and activation. DAMPs = damage-associated molecular patterns. TLR = Toll-like receptor. PAMPs = pathogen-associated molecular pattern. (B) IL-1β and IL-18 release by hMDMs ( n = 14 donors). (C) IL-1β release by mBMDMs ( n = 10). (D) IL-1β release by hMDMs in the presence of the inflammasome inhibitors KCl ( n = 8 donors) or VX-765 ( n = 9 donors). (E) Percentage ASC-positive mBMDMs ( n = 3 uninfected , n = 4 infected). (F, G) IL-1β release of mBMDMs deficient in the NLRP3 receptor ( Nlrp3 −/− ), the adapter proteins ASC ( Pycard −/− ) or the proteolytic enzyme caspase 1 ( Casp1 −/− / Casp11 −/− ) ( n = 4) or deficient in gasdermin D ( Gsdmd −/− ) (G). Bars represent the mean + SEM with dots as individual biological replicates: Individual donors (B, D) or mice (C, E - G) from at least three independently conducted experiments. Statistical significance was determined using a two-way ANOVA including with Holm-Šídák post-hoc test. * = P ≤ 0.05, ** = P ≤ 0.01, *** = P ≤ 0.001, **** = P ≤ 0.0001

    Article Snippet: For inhibitor experiments, Anakinra (recombinant human IL-1Ra, 10 μg/mL, Kineret), potassium chloride (25 mM; Merck) or the caspase-1 inhibitor VX-765 (50 μg/mL; Invivogen) were added 1 h prior to infection.

    Techniques: Activation Assay, Infection